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Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 .

J Biol Chem 2005 Feb 1;280(6):4553-67. Epub 2004 Dec 1. Department of Medicine, the University of Texas Health Science Center, San Antonio, Texas 78229, USA.

Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 .

Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes. Chandrasekar B(1), Mummidi S, Claycomb WC, Mestril R, Nemer M ...

Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 .

Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt -GATA4 Signaling Pathway in Cardiomyocytes ...

Sensitivity and Spesificity of Interleukin 18 as Biomarker for Acute Kidney Injury | Bioscientia Medicina : Journal of Biomedicine and .

Background : Incidence of AKI in intensive care unit patients reach 60-70%, and the mortality rate is about 60%. IL-18 is a pro-inflammatory cytokine which increased in endogenous inflammation process. Studies in human showed that IL-18 concentration ...

Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 .

Sigma-Aldrich offers abstracts and full-text articles by [Bysani Chandrasekar, Srinivas Mummidi, William C Claycomb, Ruben Mestril, Mona Nemer]. ... ANALYTICAL / CHROMATOGRAPHY » Standards & Reference Materials Gas Chromatography HPLC & UHPLC

Interleukin-18 as a Therapeutic Target in Acute Myocardial Infarction and Heart Failu

Interleukin-18 (IL-18) is a proinflammatory cytokine that was first described in 1989 for its ability to induce ... Claycomb WC, Mestril R, Nemer M. Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositideJ Biol ...

Elevated Serum Interleukin-18 Level Is Associated with All-Cause Mortality in Stable Hemodialysis Patients Independently of Cardiac Dysfunction .

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interleukin-18 binding protein Publications | PubFac

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Interleukin‐18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K‐Akt‐dependent NF‐κB activation - Reddy .

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Angiotensin II Enhances Interleukin-18 Mediated Inflammatory Gene Expression in Vascular Smooth Muscle Cells | Circulation Resear

functional interleukin-18 receptors (IL-18Rs), composed of α and β subunits. ... is also a proatherogenic cytokine. IL-18 is expressed in human carotid atherosclerotic plaques and this was related to plaque instability. 6 Administration of exogenous ...

INTERLEUKIN 18 IN THE HEART : Shock - L

IL-18, originally termed as interferon γ (IFN-γ) inducing factor, is a proinflammatory cytokine that belongs to the IL-1 cytokine superfamily. IL-18 plays an important role in immune, infectious, and inflammatory diseases due to its induction of IFN-γ. However, accumulated evidence has

Elevated Serum Interleukin-18 Level Is Associated with All-Cause Mortality in Stable Hemodialysis Patients Independently of Cardiac Dysfunction .

Paperity: the 1st multidisciplinary aggregator of Open Access journals & papers. Free fulltext PDF articles from hundreds of disciplines, all in one place ...

Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α .

Interleukin (IL)-18 is a potent pro-hypertrophic inflammatory cytokine. We report that induction of pressure overload in the rabbit, by constriction of the descending thoracic aorta induces ...

Cardiac thromboxane A2 receptor activation does not directly induce cardiomyocyte hypertrophy but does cause cell death that is prevented with .

Nevertheless, how TXA2R activation may specifically promote remodeling of the heart has not been fully elucidated. Since cardiac TXA2R activation increases intracellular calcium it is possible that TXA2 may activate hypertrophic signaling or lead to cell death.

Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process | The American Journal of Clinical Nutrition | Oxford Academ

BLOCKING INTERLEUKIN 18 IN MODELS OF AUTOIMMUNE DISEASE As with any cytokine, the role of IL-18 in a particular disease process is best assessed by using specific neutralization of the cytokine in a complex disease model.

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This cytokine also has a pro-growth effect on human fibroblasts, activates PMNs and induces interleukin 1, prostaglandin E2 and collagenase production.This image shows cytoplasmic staining of TNF alpha secreting cells including histiocytes/macrophages IL 18 ...

The role of the pro-inflammatory cytokine Interleukin-18, its processing enzyme Caspase-1, and potential alternative IL-18- activating pathways in .

The role of the pro-inflammatory cytokine Interleukin-18, its processing enzyme Caspase-1, and potential alternative IL-18-activating pathways in atherosclerosis Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen ...

Genetic Variants of Interleukin-18 Promoter Gene in Coronary Artery Disea

Background & objectives: Heart disease is impacted by ecological and inherited factors. Interleukin-18 (IL-18) is a pro-inflammatory cytokine that stimulates the immune reaction and induces the formation of atherosclerotic plaques. The aim of this study was to ...

Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 .

In patients with congestive heart failure, high serum levels of the proinflammatory cytokine interleukin (IL)-18 were reported. A positive correlation was described between serum IL-18 levels and the disease severity. EL-18 has also been shown to induce atrial ...

Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells - Wikida

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Interleukin 18 - Wikiped

Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. This cytokine is produced by many immune cells and can modulate ...